Synthetic Riboswitches That Induce Gene Expression in Diverse Bacterial Species
Author(s) -
Shana Topp,
Colleen M. K. Reynoso,
Jessica C. Seeliger,
Ian S. Goldlust,
Shawn K. Desai,
Dorothée Murat,
Aimee Shen,
Aaron W. Puri,
Arash Komeili,
Carolyn R. Bertozzi,
June R. Scott,
Justin P. Gallivan
Publication year - 2010
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.01537-10
Subject(s) - riboswitch , biology , computational biology , gene expression , gene , bacteria , genetics , bacterial genetics , regulation of gene expression , escherichia coli , non coding rna
We developed a series of ligand-inducible riboswitches that control gene expression in diverse species of Gram-negative and Gram-positive bacteria, including human pathogens that have few or no previously reported inducible expression systems. We anticipate that these riboswitches will be useful tools for genetic studies in a wide range of bacteria.
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