Intestinal Integrity and Akkermansia muciniphila , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly | Zendy

María Carmen Collado | Zendy; Muriel Derrien | Zendy; Erika Isolauri | Zendy; Willem M. de Vos | Zendy; Seppo Salminen | Zendy

Open Access

Intestinal Integrity and Akkermansia muciniphila , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

Author(s) -

María Carmen Collado,

Muriel Derrien,

Erika Isolauri,

Willem M. de Vos,

Seppo Salminen

Publication year - 2007

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01477-07

Subject(s) - akkermansia muciniphila , mucin , microbiology and biotechnology , biology , bacteria , ribosomal rna , 16s ribosomal rna , feces , colonization , akkermansia , gene , genetics , lactobacillus , biochemistry

Fluorescence in situ hybridization and real-time PCR analysis targeting the 16S rRNA gene of Akkermansia muciniphila were performed to determine its presence in the human intestinal tract. These techniques revealed that an A. muciniphila-like bacterium is a common member of the human intestinal tract and that its colonization starts in early life and develops within a year to a level close to that observed in adults (10(8) cells/g) but decreases (P < 0.05) in the elderly.

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