Contribution of Chitinases to Listeria monocytogenes Pathogenesis | Zendy

Swarnava Chaudhuri | Zendy; Joseph C. Bruno | Zendy; Francis Alonzo | Zendy; Bobbi Xayarath | Zendy; Nicholas P. Cianciotto | Zendy; Nancy E. Freitag | Zendy

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Contribution of Chitinases to Listeria monocytogenes Pathogenesis

Author(s) -

Swarnava Chaudhuri,

Joseph C. Bruno,

Francis Alonzo,

Bobbi Xayarath,

Nicholas P. Cianciotto,

Nancy E. Freitag

Publication year - 2010

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01338-10

Subject(s) - listeria monocytogenes , microbiology and biotechnology , chitin , chitinase , pathogenesis , biology , listeria , mutant , bacteria , enzyme , biochemistry , immunology , gene , genetics , chitosan

Listeria monocytogenes secretes two chitinases and one chitin binding protein. Mutants lackingchiA ,chiB , orlmo2467 exhibited normal growth in cultured cells but were defective for growth in the livers and spleens of mice. Mammals lack chitin; thus,L. monocytogenes may have adapted chitinases to recognize alternative substrates to enhance pathogenesis.

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