Enantioselective Dechlorination of Polychlorinated Biphenyls in Dehalococcoides mccartyi CG1

A variety of agrochemicals and pharmaceuticals are chiral. Due to the enantioselectivity in biological processes, enantiomers of chiral compounds may have different environmental occurrences, fates, and ecotoxicologies. Many chiral organohalides exist in anaerobic or anoxic soils and sediments, and organohalide-respiring bacteria play a major role in the environmental attenuation and global cycling of these chiral organohalides. Therefore, it is important to investigate the dehalogenation enantioselectivity of organohalide-respiring bacteria. This study reports the discovery of enantioselective dechlorination of chiral PCBs byDehalococcoides mccartyi CG1, which provides insights into the dehalogenation enantioselectivity ofDehalococcoides and may shed light on future PCB bioremediation efforts to prevent enantioselective biological side effects.