Interference of Mycoplasma Infection in a Gene Expression Study: It Was the Environment and Not the Gene | Zendy

Gregor Hoermann | Zendy; Joachim Spergser | Zendy; Elisa Einwallner | Zendy; Athanasios Makristathis | Zendy; Andrea Perné | Zendy; Birgit Willinger | Zendy; Ilse Schwarzinger | Zendy

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Interference of Mycoplasma Infection in a Gene Expression Study: It Was the Environment and Not the Gene

Author(s) -

Gregor Hoermann,

Joachim Spergser,

Elisa Einwallner,

Athanasios Makristathis,

Andrea Perné,

Birgit Willinger,

Ilse Schwarzinger

Publication year - 2010

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01265-10

Subject(s) - doxycycline , gene , biology , gene expression , tetracycline , gene product , mycoplasma , genetics , microbiology and biotechnology , antibiotics

We show that short-term exposure to doxycycline, as used in tetracycline-inducible gene expression models, protects cells from stress-induced death in cultures infected with Mycoplasma arginini. Coinciding with the expected maximum level of gene activity, antimicrobial effects of tetracyclines might be mistaken for antiapoptotic properties of the expressed gene product.

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