A Linear Plasmid-Like Prophage of Actinomyces odontolyticus Promotes Biofilm Assembly | Zendy

Mengyu Shen | Zendy; Yuhui Yang | Zendy; Wei Shen | Zendy; Lujia Cen | Zendy; Jeffrey S. McLean | Zendy; Wenyuan Shi | Zendy; Shuai Le | Zendy; Xuesong He | Zendy

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A Linear Plasmid-Like Prophage of Actinomyces odontolyticus Promotes Biofilm Assembly

Author(s) -

Mengyu Shen,

Yuhui Yang,

Wei Shen,

Lujia Cen,

Jeffrey S. McLean,

Wenyuan Shi,

Shuai Le,

Xuesong He

Publication year - 2018

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01263-18

Subject(s) - prophage , plasmid , biology , siphoviridae , microbiology and biotechnology , actinomyces , biofilm , bacteriophage , genetics , oral microbiome , dna , bacteria , gene , microbiome , escherichia coli

The biology of phages as members of the human oral microbiome is understudied. Here, we report the characterization of xhp1, a novel linear plasmid-like prophage identified from a human oral isolate,Actinomyces odontolyticus subsp.actinosynbacter strain XH001. xhp1 can be induced and reinfect xhp1-cured XH001. The spontaneous induction of xhp1 leads to the lysis of a subpopulation of bacterial hosts and the release of eDNA that promotes biofilm assembly, thus potentially contributing to the persistence ofA. odontolyticus within the oral cavity.

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