FinR Regulates Expression of nicC and nicX Operons, Involved in Nicotinic Acid Degradation in Pseudomonas putida KT2440 | Zendy

Yujie Xiao | Zendy; Wenjing Zhu | Zendy; Huizhong Liu | Zendy; Hailing Nie | Zendy; Wenli Chen | Zendy; Qiaoyun Huang | Zendy

Open Access

FinR Regulates Expression of nicC and nicX Operons, Involved in Nicotinic Acid Degradation in Pseudomonas putida KT2440

Author(s) -

Yujie Xiao,

Wenjing Zhu,

Huizhong Liu,

Hailing Nie,

Wenli Chen,

Qiaoyun Huang

Publication year - 2018

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01210-18

Subject(s) - pseudomonas putida , operon , degradation (telecommunications) , nicotinic agonist , biology , pseudomonas , bacteria , microbiology and biotechnology , chemistry , computational biology , biochemistry , genetics , computer science , mutant , gene , receptor , telecommunications

This study analyzed the influence offinR deletion on the transcriptomic profile ofPseudomonas putida KT2440. The FinR regulator is widely distributed but poorly studied in diverse proteobacteria. Here, we found 11 operons that potentially are regulated by FinR in KT2440. We further demonstrated that FinR played a positive role and cooperated with the NicR repressor in bacterial nicotinic acid (NA) degradation via regulating the expression ofnicC andnicX operons. Furthermore, a transcriptomic analysis also indicated a potentially negative role of FinR in the expression of thehut cluster involved in bacterial histidine utilization. The work deepened our knowledge of FinR function and nicotinic acid degradation inP. putida .

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