Quantification of Cell Proliferation and Alpha-Toxin Gene Expression ofClostridium perfringensin the Development of Necrotic Enteritis in Broiler Chickens | Zendy

Weiduo Si | Zendy; Joshua Gong | Zendy; Yanming Han | Zendy; Hai Yu | Zendy; John J. Brennan | Zendy; Huaijun Zhou | Zendy; Shu Chen | Zendy

Open Access

Quantification of Cell Proliferation and Alpha-Toxin Gene Expression ofClostridium perfringensin the Development of Necrotic Enteritis in Broiler Chickens

Author(s) -

Weiduo Si,

Joshua Gong,

Yanming Han,

Hai Yu,

John J. Brennan,

Huaijun Zhou,

Shu Chen

Publication year - 2007

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01108-07

Subject(s) - clostridium perfringens , broiler , bacitracin , toxin , biology , microbiology and biotechnology , enteritis , gene expression , gene , clostridiaceae , cell growth , clostridium , bacteria , biochemistry , antibiotics , food science , genetics

Cell proliferation and alpha-toxin gene expression of Clostridium perfringens in relation to the development of necrotic enteritis (NE) were investigated. Unlike bacitracin-treated chickens, non-bacitracin-treated birds exhibited typical NE symptoms and reduced growth performance. They also demonstrated increased C. perfringens proliferation and alpha-toxin gene expression that were positively correlated and progressed according to the regression model y = b(0) + b(1)X - b(2)X(2). The average C. perfringens count of 5 log(10) CFU/g in the ileal digesta appears to be a threshold for developing NE with a lesion score of 2.

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