Spodoptera frugiperda (J. E. Smith) Aminopeptidase N1 Is a Functional Receptor of the Bacillus thuringiensis Cry1Ca Toxin | Zendy

Isabel Gómez | Zendy; Daniel E. Rodríguez-Chamorro | Zendy; Gabriela FloresRamírez | Zendy; Ricardo Grande | Zendy; Fernando Zamudio Zuñiga | Zendy; Francisco J. Portugal | Zendy; Jorge Sánchez | Zendy; Sabino Pacheco | Zendy; Alejandra Bravo | Zendy; Mário Soberón | Zendy

Open Access

Spodoptera frugiperda (J. E. Smith) Aminopeptidase N1 Is a Functional Receptor of the Bacillus thuringiensis Cry1Ca Toxin

Author(s) -

Isabel Gómez,

Daniel E. Rodríguez-Chamorro,

Gabriela FloresRamírez,

Ricardo Grande,

Fernando Zamudio Zuñiga,

Francisco J. Portugal,

Jorge Sánchez,

Sabino Pacheco,

Alejandra Bravo,

Mário Soberón

Publication year - 2018

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01089-18

Subject(s) - spodoptera , bacillus thuringiensis , aminopeptidase , biology , toxin , toxicity , anthrax toxin , microbiology and biotechnology , genetics , gene , bacteria , recombinant dna , fusion protein , leucine , medicine , amino acid

Bacillus thuringiensis Cry toxins rely on receptor binding to exert toxicity. Cry1Ca is toxic to different populations ofS. frugiperda , a major corn pest in America. Nevertheless, theS. frugiperda midgut proteins that are involved in Cry1Ca toxicity have not been identified. Here we identified aminopeptidase N1 (APN1) as a functional receptor of Cry1Ca. Moreover, we showed that Cry1Ca domain III β16 is involved in APN1 binding. These results give insights on potential target sites for improving Cry1Ca toxicity toS. frugiperda .

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