Open AccessA Naturally Occurring Novel Allele of Escherichia coli Outer Membrane Protein A Reduces Sensitivity to Bacteriophage
Author(s) -
Michelle Power,
Belinda C. Ferrari,
Jane Littlefield-Wyer,
David M. Gordon,
Martin B. Slade,
Duncan Veal
Publication year - 2006
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.01040-06
Subject(s) - bacteriophage , escherichia coli , biology , bacterial outer membrane , dna , allele , microbiology and biotechnology , membrane protein , gene , genetics , membrane
A novel Escherichia coli outer membrane protein A (OmpA) was discovered through a proteomic investigation of cell surface proteins. DNA polymorphisms were localized to regions encoding the protein's surface-exposed loops which are known phage receptor sites. Bacteriophage sensitivity testing indicated an association between bacteriophage resistance and isolates having the novel ompA allele.