Biotransformation of Flurbiprofen by Cunninghamella Species | Zendy

Jessica Amadio | Zendy; Katherine Gordon | Zendy; Cormac D. Murphy | Zendy

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Biotransformation of Flurbiprofen by Cunninghamella Species

Author(s) -

Jessica Amadio,

Katherine Gordon,

Cormac D. Murphy

Publication year - 2010

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.01027-10

Subject(s) - biotransformation , metabolite , flurbiprofen , chromatography , chemistry , mass spectrometry , high performance liquid chromatography , gas chromatography , organic chemistry , biochemistry , biology , pharmacology , enzyme

The biotransformation of the fluorinated anti-inflammatory drug flurbiprofen was investigated in Cunninghamella spp. Mono- and dihydroxylated metabolites were detected using gas chromatography-mass spectrometry and fluorine-19 nuclear magnetic resonance spectroscopy, and the major metabolite 4'-hydroxyflurbiprofen was isolated by preparative high-pressure liquid chromatography (HPLC). Cunninghamella elegans DSM 1908 and C. blakesleeana DSM 1906 also produced a phase II (conjugated) metabolite, which was identified as the sulfated drug via deconjugation experiments.

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