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Bacteria that produce extended-spectrum beta-lactamases are resistant to an important class of antimicrobials in human and veterinary medicine. Reduction in antibiotic use is expected to decrease the prevalence of resistance. However, resistance genes often lie on plasmids which can be copied and transferred to other bacteria by conjugation, soin vitro resistance was observed to increase in the absence of antimicrobials. We sought to determine whether this also occurs in the chicken gut and if competitive exclusion by similarE. coli variants without the resistance occurred. We studied the excretion ofE. coli carrying IncI1 plasmids with thebla CTX-M-1 resistance gene in small groups of broiler chickens, after inoculating the chickens withE. coli suspensions containing different fractions of plasmid-carrying cells. Our results showed little variation between chickens within groups but large differences between groups that were independent of the ratio of variants with and without the plasmid and with persistence or extinction of the plasmid. However, there was no major plasmid increase as observedin vitro . We conclude thatin vivo studies with sufficient independent replications are important for intervention studies on plasmid-mediated antimicrobial resistance.

applied and environmental microbiology

Competition between Escherichia coli Populations with and without Plasmids Carrying a Gene Encoding Extended-Spectrum Beta-Lactamase in the Broiler Chicken Gut