Ehrlichia Isolate from a Minnesota Tick: Characterization and Genetic Transformation | Zendy

Geoffrey E. Lynn | Zendy; Nicole Y. Burkhardt | Zendy; Roderick F. Felsheim | Zendy; Curtis M. Nelson | Zendy; Jonathan D. Oliver | Zendy; Timothy J. Kurtti | Zendy; Ingrid Cornax | Zendy; M. Gerard O’Sullivan | Zendy; Ulrike G. Munderloh | Zendy

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Ehrlichia Isolate from a Minnesota Tick: Characterization and Genetic Transformation

Author(s) -

Geoffrey E. Lynn,

Nicole Y. Burkhardt,

Roderick F. Felsheim,

Curtis M. Nelson,

Jonathan D. Oliver,

Timothy J. Kurtti,

Ingrid Cornax,

M. Gerard O’Sullivan,

Ulrike G. Munderloh

Publication year - 2019

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.00866-19

Subject(s) - ehrlichia , biology , amblyomma americanum , ixodes scapularis , tick , microbiology and biotechnology , virology , ehrlichia chaffeensis , ixodidae

Ehrlichioses are zoonotic diseases caused by intracellular bacteria that are transmitted by ixodid ticks. Here we report the culture isolation of bacteria which are closely related to, or the same as theEhrlichia muris subsp.eauclairensis , a recently recognized human pathogen. EmCRT, obtained from a tick removed from deer at Camp Ripley, MN, is the second isolate of this subspecies described and is distinctive in that it was cultured directly from a field-collected tick. The isolate’s cellular tropism, pathogenic changes caused in rodent tissues, and tick transmission to and from rodents are detailed in this study. We also describe the genetic mutants created from the EmCRT isolate, which are valuable tools for the further study of this intracellular pathogen.

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