A Complex Signaling Cascade Governs Pristinamycin Biosynthesis in Streptomyces pristinaespiralis | Zendy

Yvonne Mast | Zendy; Jamil Guezguez | Zendy; Franziska Handel | Zendy; Eva Schinko | Zendy

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A Complex Signaling Cascade Governs Pristinamycin Biosynthesis in Streptomyces pristinaespiralis

Author(s) -

Yvonne Mast,

Jamil Guezguez,

Franziska Handel,

Eva Schinko

Publication year - 2015

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.00728-15

Subject(s) - streptomyces , streptomycetaceae , biosynthesis , cascade , biology , computational biology , microbiology and biotechnology , genetics , actinomycetales , chemistry , bacteria , gene , chromatography

Pristinamycin production in Streptomyces pristinaespiralis Pr11 is tightly regulated by an interplay between different repressors and activators. A γ-butyrolactone receptor gene (spbR), two TetR repressor genes (papR3 and papR5), three SARP (Streptomyces antibiotic regulatory protein) genes (papR1, papR2, and papR4), and a response regulator gene (papR6) are carried on the large 210-kb pristinamycin biosynthetic gene region of Streptomyces pristinaespiralis Pr11. A detailed investigation of all pristinamycin regulators revealed insight into a complex signaling cascade, which is responsible for the fine-tuned regulation of pristinamycin production in S. pristinaespiralis.

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