Open AccessAntibiotic Overproduction by rpsL and rsmG Mutants of Various Actinomycetes
Author(s) -
Yukinori Tanaka,
Mamoru Komatsu,
Susumu Okamoto,
Shinji Tokuyama,
Akira Kaji,
Haruo Ikeda,
Kozo Ochi
Publication year - 2009
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.00681-09
Subject(s) - streptomyces avermitilis , overproduction , mutant , biology , streptomyces , genetics , microbiology and biotechnology , antibiotics , streptomycin , gene , antibiotic resistance , regulator gene , bacteria , regulation of gene expression
Certain streptomycin resistance mutations (i.e., rpsL and rsmG) result in the overproduction of antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a further increase in antibiotic production. rpsL but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea, accompanied by increased transcription of a key developmental regulator gene, bldD, in the latter organism.
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