High-Level Biosynthesis of the Anteiso-C 17 Isoform of the Antibiotic Mycosubtilin in Bacillus subtilis and Characterization of Its Candidacidal Activity | Zendy

Patrick Fickers | Zendy; JeanSébastien Guez | Zendy; Christian Damblon | Zendy; Valérie Leclère | Zendy; Max Béchet | Zendy; Philippe Jacques | Zendy; Bernard Joris | Zendy

Open Access

High-Level Biosynthesis of the Anteiso-C ₁₇ Isoform of the Antibiotic Mycosubtilin in Bacillus subtilis and Characterization of Its Candidacidal Activity

Author(s) -

Patrick Fickers,

JeanSébastien Guez,

Christian Damblon,

Valérie Leclère,

Max Béchet,

Philippe Jacques,

Bernard Joris

Publication year - 2009

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.00548-09

Subject(s) - bacillus subtilis , lipopeptide , microbiology and biotechnology , bacillaceae , bacillales , gene isoform , biology , antibiotics , biosynthesis , strain (injury) , bacteria , biochemistry , enzyme , gene , genetics , anatomy

High-level production (880 mg liter(-1)) and isolation of the anteiso-C(17) isoform of the lipopeptide mycosubtilin produced by a genetically engineered Bacillus subtilis strain are reported. Antifungal activity of this isoform, as determined via culture and fluorometric and cell leakage assays, suggests its potential therapeutic use as an antifungal agent, in particular against Candida spp.

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