Experimental Evolution of Escherichia coli K-12 at High pH and with RpoS Induction | Zendy

Issam Hamdallah | Zendy; Nadia Torok | Zendy; Katarina M. Bischof | Zendy; Nadim Majdalani | Zendy; Sriya Chadalavada | Zendy; to Mdluli | Zendy; Kaitlin E. Creamer | Zendy; Michelle W. Clark | Zendy; Chase Holdener | Zendy; Preston J. Basting | Zendy; Susan Gottesman | Zendy; Joan L. Slonczewski | Zendy

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Experimental Evolution of Escherichia coli K-12 at High pH and with RpoS Induction

Author(s) -

Issam Hamdallah,

Nadia Torok,

Katarina M. Bischof,

Nadim Majdalani,

Sriya Chadalavada,

to Mdluli,

Kaitlin E. Creamer,

Michelle W. Clark,

Chase Holdener,

Preston J. Basting,

Susan Gottesman,

Joan L. Slonczewski

Publication year - 2018

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.00520-18

Subject(s) - rpos , escherichia coli , enterobacteriaceae , microbiology and biotechnology , bacteria , biology , chemistry , genetics , gene , gene expression , promoter

Escherichia coli in its native habitat encounters high-pH stress such as that of pancreatic secretions. Experimental evolution over 2,000 generations showed selection for mutations in regulatory factors, such as deletion of the phosphate regulator PhoB and mutations that alter the function of the global stress regulator RpoS. RpoS is induced at high pH via multiple mechanisms.

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