Functional Profiling and Crystal Structures of Isothiocyanate Hydrolases Found in Gut-Associated and Plant-Pathogenic Bacteria | Zendy

Tijs J. M. van den Bosch | Zendy; Kemin Tan | Zendy; A. Joachimiak | Zendy; Cornelia U. Welte | Zendy

Open Access

Functional Profiling and Crystal Structures of Isothiocyanate Hydrolases Found in Gut-Associated and Plant-Pathogenic Bacteria

Author(s) -

Tijs J. M. van den Bosch,

Kemin Tan,

A. Joachimiak,

Cornelia U. Welte

Publication year - 2018

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.00478-18

Subject(s) - isothiocyanate , antimicrobial , bacteria , hydrolase , allyl isothiocyanate , biology , superfamily , crop , phenethyl isothiocyanate , microorganism , biochemistry , enzyme , microbiology and biotechnology , chemistry , agronomy , genetics , gene

This study explores a newly discovered protein in the β-lactamase superfamily, namely, SaxA, or isothiocyanate hydrolase. Isothiocyanates are defensive compounds found in many cabbage-related crop plants and are currently being investigated for their antimicrobial and anticarcinogenic properties. We show that isothiocyanate hydrolases are responsible for the breakdown of several of these plant defensive chemicalsin vitro and suggest their potential for mitigating the beneficial effects of isothiocyanates in crop protection and cancer prevention.

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