Molecular Mechanism of N , N -Dimethylformamide Degradation in Methylobacterium sp. Strain DM1 | Zendy

Xinyu Lu | Zendy; Weiwei Wang | Zendy; Lige Zhang | Zendy; Haiyang Hu | Zendy; Ping Xu | Zendy; Tao Wei | Zendy; Hongzhi Tang | Zendy

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Molecular Mechanism of N , N -Dimethylformamide Degradation in Methylobacterium sp. Strain DM1

Author(s) -

Xinyu Lu,

Weiwei Wang,

Lige Zhang,

Haiyang Hu,

Ping Xu,

Tao Wei,

Hongzhi Tang

Publication year - 2019

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.00275-19

Subject(s) - methylobacterium , strain (injury) , degradation (telecommunications) , mechanism (biology) , chemistry , microbiology and biotechnology , biology , physics , computer science , gene , biochemistry , 16s ribosomal rna , telecommunications , quantum mechanics , anatomy

DMF is a hazardous pollutant that has been used in the chemical industry, pharmaceutical manufacturing, and agriculture. Biodegradation as a method for removing DMF has received increasing attention. Here, we identified an efficient DMF degrader,Methylobacterium sp. strain DM1, and characterized the complete DMF mineralization pathway and enzymatic properties of DMFase in this strain. This study provides insights into the molecular mechanisms and evolutionary advantage of DMF degradation facilitated by plasmid pLVM1 and redundant genes in strain DM1, suggesting the emergence of new ecotypes ofMethylobacterium .

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