Oxygen-Mediated Regulation of Biofilm Development Is Controlled by the Alternative Sigma Factor σ B in Staphylococcus epidermidis | Zendy

John Cotter | Zendy; James P. O’Gara | Zendy; Dietrich Mack | Zendy; Eoin Casey | Zendy

Open Access

Oxygen-Mediated Regulation of Biofilm Development Is Controlled by the Alternative Sigma Factor σ ^B in Staphylococcus epidermidis

Author(s) -

John Cotter,

James P. O’Gara,

Dietrich Mack,

Eoin Casey

Publication year - 2008

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.00261-08

Subject(s) - biofilm , staphylococcus epidermidis , sigma factor , microbiology and biotechnology , oxygen , bacterial adhesin , biology , regulator , intracellular , anaerobic exercise , staphylococcus aureus , bacteria , chemistry , biochemistry , escherichia coli , gene , genetics , physiology , organic chemistry , rna polymerase

Using a modified rotating-disk reactor to sparge oxygen to Staphylococcus epidermidis cultures, we found that oxygen negatively regulates biofilm development by influencing the activity of sigma(B). Under anaerobic conditions, increased sigma(B) activity activates icaADBC, which encodes enzymes responsible for polysaccharide intercellular adhesin synthesis, by repressing transcription of the negative regulator icaR.

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