Use of Selective Capture of Transcribed Sequences To Identify Genes Preferentially Expressed byStreptococcus suisupon Interaction with Porcine Brain Microvascular Endothelial Cells | Zendy

Nahuel Fittipaldi | Zendy; Marcelo Gottschalk | Zendy; Ghyslaine Vanier | Zendy; France Daigle | Zendy; Josée Harel | Zendy

Open Access

Use of Selective Capture of Transcribed Sequences To Identify Genes Preferentially Expressed byStreptococcus suisupon Interaction with Porcine Brain Microvascular Endothelial Cells

Author(s) -

Nahuel Fittipaldi,

Marcelo Gottschalk,

Ghyslaine Vanier,

France Daigle,

Josée Harel

Publication year - 2007

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.00258-07

Subject(s) - streptococcus suis , biology , gene , virulence , microbiology and biotechnology , pathogen , pathogenesis , genetics , immunology

By using the selective capture of transcribed sequences (SCOTS) approach, we identified 28 genes preferentially expressed by the major swine pathogen and zoonotic agent Streptococcus suis upon interaction with porcine brain microvascular endothelial cells. Several of these genes may be considered new S. suis candidate virulence factors. Results from this study demonstrate the suitability of SCOTS for the elucidation of gene expression in streptococcal species and may contribute to a better understanding of the pathogenesis of S. suis infections.

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