Disruption of the Cytoplasmic Membrane Structure and Barrier Function Underlies the Potent Antiseptic Activity of Octenidine in Gram-Positive Bacteria | Zendy

Nermina Malanović | Zendy; Jessica A. Buttress | Zendy; Djenana Vejzović | Zendy; Ayse Ön | Zendy; Paulina Piller | Zendy; Dagmar Kolb | Zendy; Karl Lohner | Zendy; Henrik Strahl | Zendy

Open Access

Disruption of the Cytoplasmic Membrane Structure and Barrier Function Underlies the Potent Antiseptic Activity of Octenidine in Gram-Positive Bacteria

Author(s) -

Nermina Malanović,

Jessica A. Buttress,

Djenana Vejzović,

Ayse Ön,

Paulina Piller,

Dagmar Kolb,

Karl Lohner,

Henrik Strahl

Publication year - 2022

Publication title -

applied and environmental microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.552

H-Index - 324

eISSN - 1070-6291

pISSN - 0099-2240

DOI - 10.1128/aem.00180-22

Subject(s) - lipid bilayer , biophysics , cell envelope , membrane , biology , cytoplasm , bacillus subtilis , cell membrane , bacteria , bacterial outer membrane , enterococcus hirae , gram negative bacteria , microbiology and biotechnology , chemistry , biochemistry , escherichia coli , enterococcus , genetics , gene

OCT is a well-established antiseptic molecule routinely used in a large field of clinical applications. Since the spread of antimicrobial resistance has restricted the use of antibiotics worldwide, topically applied antiseptics like OCT, with a broad spectrum of antimicrobial activity and high safety profile, gain increasing importance for effective infection prevention and therapy.

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