Open AccessDisruption of the Cytoplasmic Membrane Structure and Barrier Function Underlies the Potent Antiseptic Activity of Octenidine in Gram-Positive Bacteria
Author(s) -
Nermina Malanović,
Jessica A. Buttress,
Djenana Vejzovic,
Ayse Ön,
Paulina Piller,
Dagmar Kolb,
Karl Lohner,
Henrik Strahl
Publication year - 2022
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.00180-22
Subject(s) - lipid bilayer , biophysics , cell envelope , membrane , biology , cytoplasm , bacillus subtilis , cell membrane , bacteria , bacterial outer membrane , enterococcus hirae , gram negative bacteria , microbiology and biotechnology , chemistry , biochemistry , escherichia coli , enterococcus , genetics , gene
OCT is a well-established antiseptic molecule routinely used in a large field of clinical applications. Since the spread of antimicrobial resistance has restricted the use of antibiotics worldwide, topically applied antiseptics like OCT, with a broad spectrum of antimicrobial activity and high safety profile, gain increasing importance for effective infection prevention and therapy.