Activity of Amphotericin B, 5-Fluorocytosine, and Rifampin Against Six Clinical Isolates of Aspergillus | Zendy

Mitsuo Kitahara | Zendy; V. Seth | Zendy; Gerald Medoff | Zendy; G S Kobayashi | Zendy

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Activity of Amphotericin B, 5-Fluorocytosine, and Rifampin Against Six Clinical Isolates of Aspergillus

Author(s) -

Mitsuo Kitahara,

V. Seth,

Gerald Medoff,

G S Kobayashi

Publication year - 1976

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.9.6.915

Subject(s) - amphotericin b , aspergillus fumigatus , aspergillus , microbiology and biotechnology , aspergillus flavus , antibiotics , biology , flucytosine , aspergillosis , pharmacology , antifungal , immunology

Amphotericin B in combination with 5-fluorocytosine was synergistic against three clinical isolates of Aspergillus fumigatus and one of three clinical isolates of A. flavus. Amphotericin B in combination with rifampin was synergistic against all six clinical isolates of Aspergillus tested. The levels of 5-fluorocytosine and rifampin required for synergism were higher than clinically achievable concentrations when measurements of synergism were based on visual turbidity; but when the effects of the drugs were measured by inhibition of ribonucleic acid synthesis or dry-weight increase, much lower concentrations were effective.

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