Altered Ribosomes in Antibiotic-Resistant Mutants of Mycobacterium smegmatis | Zendy

Takeshi Yamada | Zendy; Kunitsugu Masuda | Zendy; Yasuo Mizuguchi | Zendy; Kiyoko Suga | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Altered Ribosomes in Antibiotic-Resistant Mutants of Mycobacterium smegmatis

Author(s) -

Takeshi Yamada,

Kunitsugu Masuda,

Yasuo Mizuguchi,

Kiyoko Suga

Publication year - 1976

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.9.5.817

Subject(s) - mycobacterium smegmatis , locus (genetics) , ribosome , biology , capreomycin , viomycin , kanamycin , mutant , streptomycin , microbiology and biotechnology , genetics , neomycin , antibiotics , gene , mycobacterium tuberculosis , rna , medicine , tuberculosis , ethambutol , pathology

Two alleles for viomycin-capreomycin resistance (vic) in Mycobacterium smegmatis affect ribosome structures. One (vicA) affects a component of 50S subunits and the other (vicB) affects a component of 30S subunits. The locus for neomycin-kanamycin resistance (nek), which is linked to vicA and vicB, affects a component of 30S subunits. Although the erythromycin resistance locus (ery) is linked to vic and nek, no ribosomal alterations could be detected. Mutations at the streptomycin locus (str) not linked to vic and nek caused alterations of 30S subunits.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research