Open AccessPirbenicillin, a New Semisynthetic Penicillin with Broad-Spectrum Activity
Author(s) -
Gerald P. Bodey,
Victorio Rodriguez,
Susanne Weaver
Publication year - 1976
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.9.4.668
Subject(s) - carbenicillin , ticarcillin , proteus mirabilis , microbiology and biotechnology , enterobacter , penicillin , serratia , providencia , proteus , pseudomonas aeruginosa , klebsiella , broad spectrum , biology , escherichia coli , antibiotics , chemistry , ampicillin , bacteria , imipenem , biochemistry , pseudomonas , antibiotic resistance , genetics , combinatorial chemistry , gene
Pirbenicillin is a new semisynthetic penicillin which inhibited 67% of isolates ofProteus aeruginosa tested in our laboratory, 93% ofP. mirabilis , 31% ofEnterobacter spp., 41% ofSerratia spp., and 58% ofEscherichia coli at a concentration of 6.25 μg/ml. Its activity appeared to be inoculum dependent and it was virtually inactive against 107 inocula ofP. aeruginosa . It was more active than carbenicillin or ticarcillin, but less active than BL-P1654 againstP. aeruginosa . Carbenicillin and ticarcillin appeared to be more active than pirbenicillin againstProteus spp., but pirbenicillin was active against some isolates ofKlebsiella spp.