4,4′-Isopropylidine-Bis[2-Isopropyl]Phenol, a New Inhibitor for Cell Wall Formation of Bacillus subtilis | Zendy

Ibrahim R. Shimi | Zendy; Safwat Shoukry | Zendy; Zeinab Zaki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

4,4′-Isopropylidine-Bis[2-Isopropyl]Phenol, a New Inhibitor for Cell Wall Formation of Bacillus subtilis

Author(s) -

Ibrahim R. Shimi,

Safwat Shoukry,

Zeinab Zaki

Publication year - 1976

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.9.4.580

Subject(s) - bacillus subtilis , biochemistry , bacterial cell structure , isopropyl , antimicrobial , chemistry , autolysis (biology) , dna ligase , cell wall , enzyme , bacteria , uridine , phenol , biology , microbiology and biotechnology , rna , organic chemistry , genetics , gene

4,4′-Isopropylidine-bis[2-isopropyl]phenol was found to possess antimicrobial activity against gram-positive bacteria and some fungi, whereas it had no effect on gram-negative organisms. The drug has a potent inhibitory action on the synthesis of cell wall mucopeptides ofBacillus subtilis by inhibiting the enzymed -glutamate ligase, which is responsible for the incorporation ofd -glutamic acid into uridine 5′-diphosphate-muramyl-l -alanine. The drug had a weak lytic effect on protoplasts and inhibited protein synthesis, whereas no significant effect on the synthesis of deoxyribonucleic acid and ribonucleic acid was found.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research