Open Access4,4′-Isopropylidine-Bis[2-Isopropyl]Phenol, a New Inhibitor for Cell Wall Formation of Bacillus subtilis
Author(s) -
Ibrahim R. Shimi,
Safwat Shoukry,
Zeinab Zaki
Publication year - 1976
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.9.4.580
Subject(s) - bacillus subtilis , biochemistry , bacterial cell structure , isopropyl , antimicrobial , chemistry , autolysis (biology) , dna ligase , cell wall , enzyme , bacteria , uridine , phenol , biology , microbiology and biotechnology , rna , organic chemistry , genetics , gene
4,4′-Isopropylidine-bis[2-isopropyl]phenol was found to possess antimicrobial activity against gram-positive bacteria and some fungi, whereas it had no effect on gram-negative organisms. The drug has a potent inhibitory action on the synthesis of cell wall mucopeptides ofBacillus subtilis by inhibiting the enzymed -glutamate ligase, which is responsible for the incorporation ofd -glutamic acid into uridine 5′-diphosphate-muramyl-l -alanine. The drug had a weak lytic effect on protoplasts and inhibited protein synthesis, whereas no significant effect on the synthesis of deoxyribonucleic acid and ribonucleic acid was found.