Open AccessConsiderations on Structure-Activity Relationships with Mengovirus of Substituted 5-Amino-4-Cyanopyrazoles
Author(s) -
Horst Willitzer,
M Tonew,
E. Lippmann
Publication year - 1976
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.9.3.367
Subject(s) - virus , yield (engineering) , virology , biology , biological activity , chemistry , stereochemistry , biochemistry , in vitro , materials science , metallurgy
In a screening program using the agar diffusion-plaque inhibition test, 22 out of 27 substituted aminopyrazoles tested showed marked antiviral activity against mengovirus in FL cell cultures. The efficacy of the different derivatives was compared by determining their effect on the yield of infectious virus after a one-step growth cycle. The antiviral activity against mengovirus correlated with the chain length of the substituents and increased or decreased according to the position of the side chain.