Open AccessRelative Morphological Effects Induced by Cefoxitin and Other Beta-Lactam Antibiotics In Vitro
Author(s) -
Sheldon B. Zimmerman,
E. O. Stapley
Publication year - 1976
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.9.2.318
Subject(s) - cefoxitin , cephaloridine , cefazolin , cephalosporin , microbiology and biotechnology , carbenicillin , cephradine , antibiotics , enterobacter cloacae , moxalactam , enterobacter , cefalotin , cefotiam , biology , chemistry , biochemistry , ampicillin , bacteria , enterobacteriaceae , escherichia coli , gene , genetics , staphylococcus aureus
Cefoxitin, a new semisynthetic cephamycin antibiotic, induced filament formation at subinhibitory concentrations with a β-lactamaseless strain ofEnterobacter cloacae (HSC 18410 M66). The extent of filament induction by cefoxitin was similar to that seen with cephalothin, cefazolin, and benzylpenicillin. Filament induction by cefoxitin was markedly less than that seen with cephalexin, carbenicillin, ticarcillin, cephradine, and cephapirin. Antibiotics which failed to induce filaments at any level tested included cephaloridine, cephacetrile, cephalosporin C, the cephamycins, 6-aminopenicillanic acid, 7-aminocephalosporanic acid, A16884, A16886, and FL-1060. Those antimicrobial agents tested which lacked an aromatic substituent in the 7-position (for cephems) or in the 6-position (for penams) did not induce filaments. These observations suggest a possible relationship between filament induction of the test organism and the molecular nature of constituents in the 7- or 6-position of β-lactams.