Open AccessBiogenetic Origin of the d -Isoleucine and N -Methyl- l -Alloisoleucine Residues in the Actinomycins
Author(s) -
Takeaki Yajima,
Kaarin T. Mason,
Edward Katz
Publication year - 1976
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.9.2.224
Subject(s) - isoleucine , chemistry , biosynthesis , stereochemistry , biochemistry , amino acid , leucine , gene
Studies with14 C-labeled isoleucine stereisomers have established thatl -alloisoleucine,d -alloisoleucine, andd -isoleucine may function as precursors for the biogenesis ofd -isoleucine andN -methyl-l -alloisoleucine residues in actinomycin.l -[14 C]isoleucine appears to be employed chiefly ford -alloisoleucine (andN -methylisoleucine [?] formation); however, its role in the biosynthesis ofd -isoleucine andN -methylalloisoleucine remains unclear. The potential pathway of biosynthesis ofd -isoleucine andN -methyl-l -isoleucine is discussed.