Open AccessPharmacological Studies with Cefamandole in Human Volunteers
Author(s) -
Burt R. Meyers,
Bruce S. Ribner,
Stanley R. Yancovitz,
Shalom Z. Hirschman
Publication year - 1976
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.9.1.140
Subject(s) - cefamandole , urine , intramuscular injection , serum concentration , chemistry , pharmacology , medicine , cephalosporin , antibiotics , biochemistry
Serum and urine concentrations were measured after administration of 0.5-and 1-g doses of cefamandole intramuscularly and intravenously to healthy volunteers. Intramuscular doses of 0.5 and 1 g yielded serum concentrations at 1 h of 14.7 and 35.6 μg/ml, respectively. Significant antibacterial concentrations persisted through h 8. Intravenous doses of 0.5 and 1 g resulted in respective peak serum levels of 21 μg/ml at 45 min and 103 μg/ml at 15 min; these serum levels rapidly declined. Very high urine concentrations were achieved during the first 8 h after injection.