Open AccessCefamandole: Antimicrobial Activity In Vitro of a New Cephalosporin
Author(s) -
Burt R. Meyers,
B Leng,
Shalom Z. Hirschman
Publication year - 1975
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.8.6.737
Subject(s) - cefamandole , microbiology and biotechnology , cephalosporin , penicillin , antimicrobial , proteus , haemophilus influenzae , staphylococcus aureus , klebsiella , minimum inhibitory concentration , biology , staphylococcus epidermidis , pseudomonas aeruginosa , antibiotics , escherichia coli , bacteria , biochemistry , genetics , gene
Cefamandole, a new cephalosporin derivative, was found to have a broad spectrum of activity against a cross-section of both gram-positive and gram-negative bacteria isolated from clinical material. Gram-positive cocci, except forStreptococcus faecalis , were very susceptible. Penicillin G-resistantStaphylococcus aureus also was susceptible to cefamandole. Minimal bactericidal concentrations for gram-positive cocci approximated the minimal inhibitory concentrations. Strains ofHaemophilus influenzae were very susceptible to the drug. Most strains ofEscherichia coli, Klebsiella sp., andProteus sp. were inhibited by low concentrations. Increasing resistance occurred with larger inocula. Strains ofPseudomonas sp. were resistant to cefamandole.