Bactericidal Activity of Combinations of Penicillin or Clindamycin with Gentamicin or Streptomycin Against Species of Viridans Streptococci | Zendy

Raymond Duperval | Zendy; Nancy J. Bill | Zendy; J E Geraci | Zendy; John A. Washington | Zendy

Open Access

Bactericidal Activity of Combinations of Penicillin or Clindamycin with Gentamicin or Streptomycin Against Species of Viridans Streptococci

Author(s) -

Raymond Duperval,

Nancy J. Bill,

J E Geraci,

John A. Washington

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.8.6.673

Subject(s) - streptomycin , microbiology and biotechnology , gentamicin , penicillin , viridans streptococci , clindamycin , streptococcus mitis , biology , streptococcaceae , streptococcus , antibiotics , bacteria , genetics

Checkerboard bactericidal studies were performed with two strains each ofStreptococcus mitis, S. salivarius , andS. sanguis , and the results were analyzed by the use of isobolograms. Synergy between penicillin and streptomycin or gentamicin was demonstrated with four strains, representing two ofS. salivarius , one ofS. sanguis , and one ofS. mitis ; the remainder were either too susceptible or too resistant to be analyzed. Clindamycin with streptomycin or gentamicin acted synergistically with three strains, representing two ofS. sanguis and one ofS. salivarius ; the remainder were either too susceptible or too resistant to be analyzed.

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