Open AccessMinimal Inhibitory Concentration of Dapsone for Mycobacterium leprae in Rats
Author(s) -
John H. Peters,
Gordon Gr,
John F. Murray,
A H Fieldsteel,
Louis Levy
Publication year - 1975
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.8.5.551
Subject(s) - dapsone , mycobacterium leprae , minimum inhibitory concentration , leprosy , microbiology and biotechnology , inoculation , biology , inhibitory postsynaptic potential , chemistry , pharmacology , endocrinology , immunology , antibiotics
To define the minimal inhibitory concentration (MIC) of dapsone (DDS) forMycobacterium leprae in rats, we determined the relationship between dietary and plasma levels of DDS in uninfected male and female Lewis rats. This knowledge was applied to the design of experiments using rats inoculated in the footpads withM. leprae . The MIC for DDS in male and female rats, respectively, was 1.5 to 4.0 ng and 1.8 to 3.0 ng of DDS/ml of plasma, even though the sexes exhibited markedly different concentrations of DDS when receiving the same dietary level of DDS. These values for the MIC of DDS forM. leprae in rats are nearly identical to the previously determined MIC of DDS forM. leprae in mice.