Inhibition of Vesicular Stomatitis Virus Replication by Poly(2′-Fluoro-2′-Deoxyuridylic Acid) | Zendy

Josephine C. Grosch | Zendy; Robert J. Erickson | Zendy

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Inhibition of Vesicular Stomatitis Virus Replication by Poly(2′-Fluoro-2′-Deoxyuridylic Acid)

Author(s) -

Josephine C. Grosch,

Robert J. Erickson

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.8.5.544

Subject(s) - polynucleotide , vesicular stomatitis virus , nucleic acid , vesicular stomatitis indiana virus , rna , polymerase , virus , viral replication , biology , dna , microbiology and biotechnology , virology , chemistry , rna polymerase , biochemistry , gene

Poly(2'-fluoro-2'-deoxyuridylic acid) is known to be an effective inhibitor of the deoxyribonucleic acid polymerase found within the oncornaviruses. This synthetic polynucleotide was found to inhibit the replication of vesicular stomatitis virus in mouse L cells. The polymer was shown to be capable of inhibiting the viral ribonucleic acid (RNA)-dependent RNA polymerase, and it is proposed that this is the mechanism of antiviral activity. The following observations support this viewpoint: (i) the polymer is most active when added after virus adsorption; (ii) the antiviral activity is not species specific; and (iii) the polynucleotide is nontoxic to the host cell. Conventional methodologies designed to increase nucleic acid uptake by cultured cells do not show an increase in antiviral potency.

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