Open AccessPharmacokinetics of Minocycline in Renal Failure
Author(s) -
Peter G. Welling,
W. R. Shaw,
Stephen J. Uman,
Francis L. S. Tse,
William A. Craig
Publication year - 1975
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.8.5.532
Subject(s) - pharmacokinetics , medicine , minocycline , uremia , renal function , antibiotics , pharmacology , oral administration , antibacterial agent , regimen , impaired renal function , chemistry , biochemistry
The pharmacokinetics of minocycline have been studied after single intravenous infusions and repeated oral doses to human subjects with varying degrees of renal impairment. There was no evidence of reduced drug clearance with reduced renal function after intravenous doses although there appeared to be an increase in the tissue distribution of antibiotic in the body in uremia. After identical multiple oral dosage regimens serum levels of antibiotic were comparable in normal and mildly uremic subjects. There was no evidence of renal toxicity in normal or uremic subjects with the repeated dosage regimen used.