Response of Yeast and Mycelial Phases of Histoplasma capsulatum to Amphotericin B and Actinomycin D | Zendy

S.C. Cheung | Zendy; Gerald Medoff | Zendy; David Schlessinger | Zendy; G S Kobayashi | Zendy

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Response of Yeast and Mycelial Phases of Histoplasma capsulatum to Amphotericin B and Actinomycin D

Author(s) -

S.C. Cheung,

Gerald Medoff,

David Schlessinger,

G S Kobayashi

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.8.4.498

Subject(s) - histoplasma capsulatum , amphotericin b , dimorphic fungus , yeast , mycelium , polyene , microbiology and biotechnology , antibiotics , histoplasma , biology , fungus , histoplasmosis , antifungal , botany , biochemistry , immunology

The dimorphic fungus Histoplasma capsulatum exists in two phases: a unicellular yeast form at 37 C and a mycelium at 25 C. We have found that these two phases have selective drug susceptibilities. The mycelial form of H. capsulatum was much more susceptible to the polyene antibiotic amphotericin B than the yeast form; in contrast, the yeast form was more susceptible to the antibiotic actinomycin D. The changes in susceptibility occurred early in the transition between the two phases and permitted the transitions to be blocked by sublethal concentrations of the appropriate drugs.

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