Open AccessIrreversible Inhibition of Herpes Simplex Virus Replication in BSC-1 Cells by Zinc Ions
Author(s) -
Y Jerold Gordon,
Yael Asher,
Yechiel Becker
Publication year - 1975
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.8.3.377
Subject(s) - herpes simplex virus , zinc , centrifugation , virus , virology , viral replication , chemistry , biology , microbiology and biotechnology , biochemistry , organic chemistry
Zinc sulfate added to the medium of herpes simplex virus-infected BSC-1 cells, at a concentration of 0.1 mM, inhibited the synthesis of infectious virus progeny by 95 to 96%. A concentration of 0.2 mM zinc sulfate inhibited herpes simplex virus synthesis by 99.8% as determined by centrifugation in sucrose gradients and by plaque assay on BSC-1 monolayers. The inhibition of herpes simplex virus replication in BSC-1 cells was found to be irreversible.