Fermentation, Isolation, and Antitumor Activity of Sterigmatocystins | Zendy

William T. Bradner | Zendy; James Bush | Zendy; Robert W. Myllymaki | Zendy; Donald E. Nettleton | Zendy; F. A. O''HERRON | Zendy

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Fermentation, Isolation, and Antitumor Activity of Sterigmatocystins

Author(s) -

William T. Bradner,

James Bush,

Robert W. Myllymaki,

Donald E. Nettleton,

F. A. O''HERRON

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.8.2.159

Subject(s) - sterigmatocystin , mycotoxin , aflatoxin , mycelium , fermentation , isolation (microbiology) , chemistry , aspergillus , biology , biochemistry , microbiology and biotechnology , food science , botany

In a screening program for antitumor substances from microbial fermentations, a compound was isolated from the mycelium of an Aspergillus species which proved to be the mycotoxin 5-methoxysterigmatocystin. This and the subsequently isolated sterigmatocystin gave significant inhibition of the transplanted mouse leukemias P-388 and L-1210. Preparation and testing of several derivatives of 5-methoxysterigmatocystin suggest that certain functions in the molecule are essential for tumor inhibition. Although slight antitumor effects have been reported for the chemically related aflatoxins, we believe this is the first report of antitumor activity of sterigmatocystins.

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