Pipemidic Acid, a New Antibacterial Agent Active Against Pseudomonas aeruginosa : In Vitro Properties | Zendy

Masanao Shimizu | Zendy; Yoshiyuki Takase | Zendy; Shinichi Nakamura | Zendy; Hiromi Katae | Zendy; Akira Minami | Zendy; Katsuhisa Nakata | Zendy; Satoru Inoue | Zendy; Masamitsu Ishiyama | Zendy; Yuji Kubo | Zendy

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Pipemidic Acid, a New Antibacterial Agent Active Against Pseudomonas aeruginosa : In Vitro Properties

Author(s) -

Masanao Shimizu,

Yoshiyuki Takase,

Shinichi Nakamura,

Hiromi Katae,

Akira Minami,

Katsuhisa Nakata,

Satoru Inoue,

Masamitsu Ishiyama,

Yuji Kubo

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.8.2.132

Subject(s) - nalidixic acid , pseudomonas aeruginosa , chemistry , bacteria , microbiology and biotechnology , antibacterial agent , antibacterial activity , minimum inhibitory concentration , antibiotics , biochemistry , biology , antibiotic resistance , genetics

Pipemidic acid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-pyrido [2,3-d]pyrimidine-6-carboxylic acid, is a new derivative of piromidic acid. It is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Its potency is generally greater than that of piromidic acid and nalidixic acid. Cross-resistance is not observed between pipemidic acid and various antibiotics, and most of bacteria resistant to piromidic acid and nalidixic acid are moderately susceptible to pipemidic acid. The activity of pipemidic acid is scarcely affected by the addition of serum, sodium cholate, or change of medium pH, but is subject to the influence of inoculum size. Its action is bactericidal above minimal inhibitory concentrations.

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