Rapid Detection of Ampicillin-Resistant Haemophilus influenzae and Their Susceptibility to Sixteen Antibiotics | Zendy

Robert B. Kammer | Zendy; David A. Preston | Zendy; Jan R. Turner | Zendy; Lois C. Hawley | Zendy

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Rapid Detection of Ampicillin-Resistant Haemophilus influenzae and Their Susceptibility to Sixteen Antibiotics

Author(s) -

Robert B. Kammer,

David A. Preston,

Jan R. Turner,

Lois C. Hawley

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.8.1.91

Subject(s) - ampicillin , microbiology and biotechnology , carbenicillin , haemophilus influenzae , cefamandole , ticarcillin , cephalosporin , tetracycline , antibiotics , chloramphenicol , biology , amp resistance , minimum inhibitory concentration , antibiotic resistance , imipenem

Ampicillin-resistant and -susceptible strains of Haemophilus influenzae were tested for susceptibility to 16 antibiotics. Chloramphenicol and a new cephalosporin, cefamandole, were most active with minimal inhibitory concentrations (MICs) for all bacteria tested between 0.5 to 2.0 mug/ml. All but two organisms were susceptible to tetracycline. Ampicillin-resistant strains of H. influenzae were less susceptible (MIC, 4 to 32 mug/ml) to carbenicillin and ticarcillin than ampicillin-susceptible organisms (MIC, 0.25 to 1.0 mug/ml). A rapid assay for beta-lactamase, utilizing a chromogenic cephalosporin substrate, detected enzyme production in all 17 ampicillin-resistant strains of H. influenzae.

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