Inhibition of Ribosomal A Site Functions by Sporangiomycin and Micrococcin | Zendy

Eric Cundliffe | Zendy; Peter D. Dixon | Zendy

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Inhibition of Ribosomal A Site Functions by Sporangiomycin and Micrococcin

Author(s) -

Eric Cundliffe,

Peter D. Dixon

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.8.1.1

Subject(s) - thiostrepton , ribosome , ribosomal rna , guanosine , guanine , a site , transfer rna , binding site , biology , p site , ribosomal binding site , 50s , peptidyl transferase , biochemistry , guanosine triphosphate , nucleotide , microbiology and biotechnology , rna , gene

Sporangiomycin and micrococcin inhibit the binding of aminoacyl-transfer ribonucleic acid into the ribosomal A site in intact bacterial protoplasts. They also prevent the assembly of [ribosome-elongation factor G-guanine nucleotide] complexes in vitro and compete with [(35)S]thiostrepton for ribosomal binding sites. We conclude that micrococcin and sporangiomycin block the ribosomal A site in the vicinity of the complex guanosine triphosphatase center and so resemble thiostrepton in their modes of action.

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