Open AccessCycloheximide Production by Streptomyces griseus : Control Mechanisms of Cycloheximide Biosynthesis
Author(s) -
L. A. Kominek
Publication year - 1975
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.7.6.856
Subject(s) - cycloheximide , streptomyces griseus , biosynthesis , biochemistry , protein biosynthesis , fermentation , biology , protein synthesis inhibitor , streptomyces , microbiology and biotechnology , bacteria , enzyme , genetics
Cycloheximide accumulation in a fermentation medium has been shown to be the product of the balance between synthesis and degradation of this antibiotic. Glucose has been shown to prevent cycloheximide degradation. Cycloheximide has been shown to interfere with its own synthesis probably due to feedback inhibition. Approaches for increasing cycloheximide titers in the light of these findings are discussed.
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