Open AccessEffects of cis -Dichlorodiammineplatinum (II) and Related Transition Metal Complexes on Escherichia coli
Author(s) -
C. MontiBragadin,
L. Ramani,
L. Samer,
G. Mestroni,
G. Zassinovich
Publication year - 1975
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.7.6.825
Subject(s) - prophage , escherichia coli , ruthenium , chemistry , rhodium , growth inhibition , strain (injury) , stereochemistry , medicinal chemistry , biology , in vitro , biochemistry , bacteriophage , gene , catalysis , anatomy
A number of transition metal complexes, including thecis andtrans isomers of dichlorodiammineplatinum (II), six complexes of rhodium (I), two of iridium (I), and one of ruthenium (II) have been tested for their ability to induce lambda prophage, to produce filamentous growth ofEscherichia coli , and to be selectively toxic for strains with defects in the deoxyribonucleic acid repair system. Dichlorotetrakis(dimethylsulfoxide)ruthenium II [RuCl2 (DMSO)4 ] was strictly similar tocis -dichlorodiammineplatinum II [cis PtCl2 (NH3 )2 ] in the test for lambda induction, filamentous growth production, and selective toxicity for arecA − strain. [Rh COD 1,10-phenanthroline]+ Cl− , though more toxic forrecA − than forrec + E. coli , was scarcely effective in the test for filamentous growth and did not induce prophage. None of the other tested compounds showed any similarity withcis -PtCl2 (NH3 )2 . Due to the interesting results obtained withcis -PtCl2 (NH3 )2 as an antitumor agent, it seems reasonable to propose RuCl2 (DMSO)4 as a potential antitumor substance.