Differential Potentiation by Nystatin of the Effect of Antibiotics on Yeast and Mammalian Cells | Zendy

Adorján Aszalós | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Differential Potentiation by Nystatin of the Effect of Antibiotics on Yeast and Mammalian Cells

Author(s) -

Adorján Aszalós

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.7.6.754

Subject(s) - nystatin , chinese hamster ovary cell , yeast , candida albicans , antibiotics , polyene , microbiology and biotechnology , biology , hamster , biochemistry , chemistry , cell culture , genetics

The effect of the polyene antibiotic nystatin, used in combination with several other antibiotics, on the membranes of Candida albicans SC#8169 (yeast) cells and of Chinese hamster ovary and 3T3 (mammalian) cells was investigated. It was concluded from determinations of the viability of the yeast cells and from measurements of deoxyribonucleic acid synthesis by the mammalian cells that nystatin acts synergistically with several antibiotics on yeast cells, but not on CHO and 3T3 cells. This selective action of nystatin may prove useful in chemotherapy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research