In Vivo Protection of Fusobacterium necrophorum from Penicillin by Bacteroides fragilis | Zendy

Abigail S. Hackman | Zendy; T D Wilkins | Zendy

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In Vivo Protection of Fusobacterium necrophorum from Penicillin by Bacteroides fragilis

Author(s) -

Abigail S. Hackman,

T D Wilkins

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.7.5.698

Subject(s) - bacteroides fragilis , fusobacterium necrophorum , penicillin , microbiology and biotechnology , bacteroidaceae , in vivo , fusobacterium , biology , antibiotics , in vitro , virology , bacteria , bacteroides , biochemistry , genetics

A mixed infection ofBacteroides fragilis andFusobacterium necrophorum was resistant to treatment with penicillin even though a pureF. necrophorum infection could be successfully treated with penicillin. SinceB. fragilis alone did not produce infection, these results indicate thatB. fragilis can protectF. necrophorum from penicillin in vivo. The extent of protection afforded by a strain ofB. fragilis was related to its level of resistance to penicillin. Only a few cells ofB. fragilis were required in the initial bacterial injection. Moreover, protection was demonstrated whenB. fragilis cells were injected as late as 24 h after theF. necrophorum cells. Protection ofF. necrophorum from penicillin byB. fragilis was also demonstrated in vitro.

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