Pharmacokinetic Interpretation of Blood Levels and Urinary Excretion Data for Cefazolin and Cephalothin After Intravenous and Intramuscular Administration in Humans | Zendy

Elisabeth S. Rattie | Zendy; Louis J. Ravin | Zendy

Open Access

Pharmacokinetic Interpretation of Blood Levels and Urinary Excretion Data for Cefazolin and Cephalothin After Intravenous and Intramuscular Administration in Humans

Author(s) -

Elisabeth S. Rattie,

Louis J. Ravin

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.7.5.606

Subject(s) - cefazolin , pharmacokinetics , elimination rate constant , bioavailability , pharmacology , intramuscular injection , distribution (mathematics) , crossover study , medicine , anesthesia , chemistry , volume of distribution , antibiotics , pathology , mathematical analysis , biochemistry , alternative medicine , mathematics , placebo

Blood levels of cefazolin and cephalothin were determined in two separate crossover studies in 20 healthy male adults, each after intravenous and intramuscular administration. Pharmacokinetic parameters were calculated from the intravenous data based upon a two-compartment open model. The rate constants controlling the distribution between the central and peripheral compartments, the overall elimination rate constants, the apparent volumes of distribution, and the fraction of the dose in the central and peripheral compartments were determined. The bioavailability was calculated to be 100% for cefazolin and cephalothin.

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