In Vivo Efficacy of 81.723 hfu, a New Pleuromutilin Derivative Against Experimentally Induced Airsacculitis in Chicks and Turkey Poults | Zendy

G. Laber | Zendy; E Schütze | Zendy

Open Access

In Vivo Efficacy of 81.723 hfu, a New Pleuromutilin Derivative Against Experimentally Induced Airsacculitis in Chicks and Turkey Poults

Author(s) -

G. Laber,

E Schütze

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.7.5.517

Subject(s) - tylosin , in vivo , derivative (finance) , chemistry , bromide , microbiology and biotechnology , biology , antibiotics , organic chemistry , financial economics , economics

The efficacy of the pleuromutilin derivative 81.723 hfu was tested in chicks and turkey poults by experimentally infecting them with Mycoplasma gallisepticum. The data were treated to obtain the mean effective doses, and these were compared to those obtained with tylosin tartrate. The compounds were administered either by ingluvial catheter or via the drinking water. Therapy was started on the day of inoculation or 7 days thereafter, respectively. The experiments showed that the compound 81.723 hfu was significantly more active in chickens than tylosin tartrate by both methods of administration of drinking water. In turkey poults the pleuromutilin derivative and tylosin tartrate had comparable activity.

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