Open AccessMechanism of Action of Anti-Influenza Benzamidine Derivatives
Author(s) -
Haruhisa Fujita,
Yoshiko Seto,
Shigeshi Toyoshima
Publication year - 1975
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.7.4.426
Subject(s) - benzamidine , mechanism of action , in vivo , pharmacology , virus , drug , biology , mechanism (biology) , virology , chemistry , in vitro , biochemistry , enzyme , genetics , philosophy , epistemology
Benzamidine derivatives exhibited a high antiviral effect in vivo against influenza virus strains A2/Adachi and B/Lee. The inhibiting properties of anti-influenza benzamidine derivatives on the virus-induced inflammation undoubtedly plays an important role in the clarification of the mechanism of action of these drugs.
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