Desferrioxamine B, an Inhibitor of Escherichia coli Motility, Reversing the Stimulating Effect of Cyclic Adenosine 3′,5′-Monophosphate | Zendy

Hiromi Maruyama | Zendy; H. Azuma | Zendy; Yoshiaki Kotoh | Zendy; Yasuji Suhara | Zendy

Open Access

Desferrioxamine B, an Inhibitor of Escherichia coli Motility, Reversing the Stimulating Effect of Cyclic Adenosine 3′,5′-Monophosphate

Author(s) -

Hiromi Maruyama,

H. Azuma,

Yoshiaki Kotoh,

Yasuji Suhara

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.7.3.377

Subject(s) - motility , escherichia coli , adenosine , cyclic adenosine monophosphate , stimulation , biochemistry , enzyme , cyclic nucleotide , biology , chemistry , microbiology and biotechnology , nucleotide , endocrinology , receptor , gene

A substance inhibiting Escherichia coli motility was isolated by "motilometry" assay from the culture broth of Streptomyces sp. strain NR9GG8 and was found to be identical with desferrioxamine B. Its inhibitory effect was reversed by cyclic adenosine 3',5'-monophosphate (cAMP), while the motility stimulation by cAMP was diminished by this inhibitor. Its effects on various enzymes involved in cAMP metabolism of function of cAMP were examined.

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