Phosphonoacetic Acid-Resistant Herpes Simplex Virus Infection in Hairless Mice | Zendy

Richard J. Klein | Zendy; Alvin E. FriedmanKien | Zendy

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Phosphonoacetic Acid-Resistant Herpes Simplex Virus Infection in Hairless Mice

Author(s) -

Richard J. Klein,

Alvin E. FriedmanKien

Publication year - 1975

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.7.3.289

Subject(s) - hairless , virology , herpes simplex virus , virus , biology , microbiology and biotechnology , genetics

Phosphonoacetic acid (PAA)-resistant type 1 herpes simplex virus population was isolated by repeated passage of the virus in the presence of this inhibitor. Hairless mice infected percutaneously with the inhibitor-resistant or the parental inhibitor-susceptible virus were treated intraperitoneally with PAA and 9-β-d -arabinofuranosyl-adenine by using several different dosage schedules. Whereas 9-β-d -arabinofuranosyl-adenine was effective both in the PAA-susceptible and PAA-resistant herpes simplex virus-induced skin infection, PAA suppressed only the infection induced by the parental PAA-susceptible virus.

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